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CAS No.: 1187594-09-7
Synonyms: LY3009104;INCB028050;Olumiant
Baricitinib can selectively inhibit JAK1/2 inhibitor with IC50 values of 5.9 nM and 5.7 nM.
生物活性
靶点 | JAK1 IC50:5.9nM | JAK2 IC50:5.7nM |
动物研究 | |
剂量 | Rats: min = 1 mg/kg, max = 10 mg/kg[2] (p.o.) |
给药途径 | p.o. |
NCT号 | 适应症或疾病 | 临床期 | 招募状态 | 预计完成时间 | 地点 |
---|---|---|---|---|---|
NCT03440892 | - | - | Recruiting | January 2020 | Sweden ... more >> Dept of Rheumatology and Inflammation research Recruiting Gothenburg, Sweden Contact: Sofia T Silfverswärd sofia.silfversward@rheuma.gu.se Collapse << |
NCT01185353 | Arthritis, Rheumatoid | Phase 2 | Completed | - | - |
NCT01398475 | Chronic Inflammatory Disorder ... more >> Arthritis, Rheumatoid Collapse << | Phase 1 | Completed | - | Singapore ... more >> For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician. Singapore, Singapore, 117597 Collapse << |
实验方案
技术信息
CAS号 | 1187594-09-7 | 储存条件 |
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分子式 | C16H17N7O2S | 运输 | 蓝冰 | |||||||||||
分子量 | 371.42 | 别名 | LY3009104;INCB028050;Olumiant;巴瑞替尼 | |||||||||||
溶解度 |
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动物实验配方 |
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Cell Lines | Concentration | Assay Type | Time | Activity Description | Data Sources |
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human CD34+ cells | - | Function assay | 45 mins | Inhibition of JAK2 homodimer in human CD34+ cells spiked into human whole blood assessed as inhibition of EPO-induced STAT-5 phosphorylation preincubated for 45 mins followed by EPO addition measured after 15 mins by FACS analysis, IC50=0.0878μM | 24417533 |
human TF1 cells | - | Function assay | - | Inhibition of JAK1 in human TF1 cells assessed as suppression of IL6-stimulated STAT3 phosphorylation by AlphaScreen assay | 26372653 |
human UT7 cells | - | Function assay | - | Inhibition of JAK2 in human UT7 cells assessed as suppression of EPO-stimulated STAT5 phosphorylation by AlphaScreen assay | 26372653 |
NCT号 | 适应症或疾病 | 临床期 | 招募状态 | 预计完成时间 | 地点 |
---|
NCT03440892 | - | - | Recruiting | January 2020 | Sweden ... more >> Dept of Rheumatology and Inflammation research Recruiting Gothenburg, Sweden Contact: Sofia T Silfverswärd sofia.silfversward@rheuma.gu.se Collapse << |
NCT01185353 | Arthritis, Rheumatoid | Phase 2 | Completed | - | - |
NCT01398475 | Chronic Inflammatory Disorder ... more >> Arthritis, Rheumatoid Collapse << | Phase 1 | Completed | - | Singapore ... more >> For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician. Singapore, Singapore, 117597 Collapse << |
NCT00902486 | Rheumatoid Arthritis | Phase 2 | Completed | - | - |
NCT01710358 | Rheumatoid Arthritis | Phase 3 | Completed | - | - |
NCT01185353 | - | - | Completed | - | - |
NCT01398475 | - | - | Completed | - | - |
NCT01721057 | Rheumatoid Arthritis | Phase 3 | Completed | - | - |
NCT01710358 | - | - | Completed | - | - |
NCT01469013 | Arthritis, Rheumatoid | Phase 2 | Completed | - | Japan ... more >> For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician. Chiba, Japan, 260-8712 For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician. Fukuoka, Japan, 812-0025 For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician. Hiroshima, Japan, 730-0017 For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician. Hokkaido, Japan, 063-0811 For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician. Hyogo, Japan, 673-1462 For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician. Ibaragi, Japan, 316-0035 For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician. Kagoshima, Japan, 890-0067 For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician. Kanagawa, Japan, 252-0392 For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician. Nagasaki, Japan, 857-1165 For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician. Oita, Japan, 870-0823 For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician. Okayama, Japan, 700-8607 For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician. Osaka, Japan, 586-8521 For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician. Tokyo, Japan, 130-0013 For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician. Toyama, Japan, 933-0874 Collapse << |
NCT01724580 | - | - | - | - | United States, Maryland ... more >> Translational Autoinflammatory Disease (TADS) Bethesda, Maryland, United States, 20892 United States, Pennsylvania Children's Hospital of Philadelphia Philadelphia, Pennsylvania, United States, 19104 United Kingdom Great Ormond Street Hospital London, United Kingdom, WC1N 1EH Collapse << |
NCT00902486 | - | - | Completed | - | - |
NCT01711359 | - | - | Completed | - | - |
NCT01721057 | - | - | Completed | - | - |
NCT01711359 | Rheumatoid Arthritis | Phase 3 | Completed | - | - |
NCT01247350 | Healthy Volunteer | Phase 1 | Completed | - | United States, Hawaii ... more >> For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician. Honolulu, Hawaii, United States Collapse << |
NCT01247350 | - | - | Completed | - | - |
NCT01469013 | - | - | Completed | - | - |
NCT01885078 | Rheumatoid Arthritis | Phase 3 | Active, not recruiting | March 22, 2024 | - |
NCT03755466 | Rheumatoid Arthritis | Phase 2 | Recruiting | November 20, 2023 | Japan ... more >> Yukio Nakamura Recruiting Matsumoto, Nagano, Japan, 3908621 Contact: Yukio Nakamura, MD, PhD +81-263-37-2659 yxn14@aol.jp Principal Investigator: Yukio Nakamura, MD, PhD Collapse << |
NCT01536951 | - | - | Completed | - | - |
NCT01536951 | Healthy Participants | Phase 1 | Completed | - | United States, Florida ... more >> For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician. Daytona Beach, Florida, United States, 32117 Collapse << |
NCT01683409 | Diabetic Kidney Disease | Phase 2 | Completed | - | - |
NCT01299285 | Healthy Volunteers | Phase 1 | Completed | - | United States, Wisconsin ... more >> For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559), Mon - Fri, 9AM to 5PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician. Madison, Wisconsin, United States Collapse << |
NCT01721044 | Rheumatoid Arthritis | Phase 3 | Completed | - | - |
NCT03428100 | Atopic Dermatitis | Phase 3 | Recruiting | March 1, 2021 | - |
NCT02576938 | Atopic Dermatitis | Phase 2 | Completed | - | United States, California ... more >> Dermatology Research Associates Los Angeles, California, United States, 90045 United States, Florida Forward Clinical Trials, Inc Tampa, Florida, United States, 33624 United States, Georgia Medical Dermatology Specialists Atlanta, Georgia, United States, 30342 United States, Illinois Northwestern University Chicago, Illinois, United States, 60611 United States, New York Icahn School of Medicine New York, New York, United States, 10029 United States, Oregon Oregon Health and Science University Portland, Oregon, United States, 97239 United States, Texas Menter Dermatology Research Institute Dallas, Texas, United States, 75246 Center for Clinical Studies Houston, Texas, United States, 77004 Center for Clinical Studies Houston, Texas, United States, 77065 Center for Clinical Studies Webster, Texas, United States, 77598 Japan For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician. Fukuoka-shi, Japan, 815-0082 For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician. Sapporo, Japan, 060-0063 For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician Takaoka-shi, Japan, 933-0871 Collapse << |
NCT02576938 | - | - | Completed | - | - |
NCT03334435 | Atopic Dermatitis | Phase 3 | Recruiting | August 27, 2021 | - |
NCT01683409 | - | - | Completed | - | - |
NCT01299285 | - | - | Completed | - | - |
NCT03733301 | Atopic Dermatitis | Phase 3 | Recruiting | August 28, 2019 | - |
NCT01960140 | - | - | Completed | - | - |
NCT01960140 | Healthy Volunteers | Phase 1 | Completed | - | United Kingdom ... more >> For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician. Leeds, West Yorkshire, United Kingdom, LS2 9LH Collapse << |
NCT01490632 | Psoriasis Ski... more >>n Diseases Skin Diseases, Papulosquamous Collapse << | Phase 2 | Completed | - | - |
NCT01721044 | - | - | Completed | - | - |
NCT02265705 | Rheumatoid Arthritis | Phase 3 | Completed | - | Argentina ... more >> For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician. Ciudad Autonoma de Buenos Aire, Argentina, C1015ABO For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician. Ciudad Autonoma de Buenos Aire, Argentina, C1431FWO For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician. Ciudad Autonoma de Buenos Aire, Argentina, C1440AAD For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician. Rosario, Argentina, S2000CFJ For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician. San Juan, Argentina, J5402DIL For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician. San Miguel De Tucuman, Argentina, T4000AXL Brazil For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician. Sao Paulo, Brazil, 04266-010 For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician. São Paulo, Brazil, 01244-030 China For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician. Beijing, China, 100029 For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician. Beijing, China, 100044 For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician. Bengbu, China, 233004 For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician. Changsha, China, 410008 For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician. Changsha, China, 410011 For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician. Chengdu, China, 610041 For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician. Guangzhou, China, 510080 For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician. Hefei, China, 230001 For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician. Hefei, China, 230022 For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician. Jinan, China, 250012 For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician. Kunming, China, 650032 For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician. Nanjing, China, 210029 For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician. Ningbo, China, 315010 For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician. Pingxiang, China, 337055 For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician. Shanghai, China, 200001 For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician. Shanghai, China, 200032 For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician. Shanghai, China, 200052 For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician. Shantou, China, 515041 For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician. Tianjin, China, 300052 For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician. Wuhan City, China, 430030 For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician. Yancheng, China, 224005 For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician. ZhuZhou, China, 412007 Collapse << |
NCT01924299 | Healthy Volunteers | Phase 1 | Completed | - | United Kingdom ... more >> For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician. Leeds, West Yorkshire, United Kingdom, LS2 9LH Collapse << |
NCT03334396 | Atopic Dermatitis | Phase 3 | Recruiting | August 15, 2019 | - |
NCT01859078 | Healthy Volunteers | Phase 1 | Completed | - | United Kingdom ... more >> For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician. Leeds, West Yorkshire, United Kingdom, LS2 9LH Collapse << |
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NCT03742973 | Primary Biliary Cholangitis | Phase 2 | Not yet recruiting | October 15, 2020 | United States, California ... more >> Southern California GI and Liver Centers (SCLC) Not yet recruiting Coronado, California, United States, 92118 Contact 619-522-0399 Principal Investigator: Tarek Hassanein Cedars-Sinai Comprehensive Transplant Center Not yet recruiting Los Angeles, California, United States, 90048 Contact 310-423-6000 Principal Investigator: Vinay Sundaram UC Davis Transplant Research Not yet recruiting Sacramento, California, United States, 95816 Contact 916-734-0779 Principal Investigator: Christopher Bowlus United States, Colorado University of Colorado School of Medicine Not yet recruiting Aurora, Colorado, United States, 80045 Contact 728-848-2292 Principal Investigator: Lisa Forman United States, Florida Florida Digestive Health Specialists Not yet recruiting Lakewood Ranch, Florida, United States, 34211 Contact 941-727-7772 Principal Investigator: Guy W Neff Schiff Center for Liver Diseases/University of Miami Not yet recruiting Miami, Florida, United States, 33136 Contact 305-243-4615 Principal Investigator: Cynthia Levy United States, Louisiana Tulane University School of Medicine Not yet recruiting New Orleans, Louisiana, United States, 70112 Contact 504-988-5344 Principal Investigator: Fredric Regenstein United States, Maryland The Institute for Digestive Health and Liver Disease at Mercy Not yet recruiting Baltimore, Maryland, United States, 21202 Contact 410-332-9356 Principal Investigator: Paul Thuluvath United States, Michigan Henry Ford Hospital Not yet recruiting Detroit, Michigan, United States, 48202 Contact 313-916-9465 Principal Investigator: Stuart Gordon United States, Minnesota Mayo Clinic Not yet recruiting Rochester, Minnesota, United States, 55905 Contact 507-284-3917 Principal Investigator: John Eaton United States, Missouri St Louis University School of Medicine Not yet recruiting Saint Louis, Missouri, United States, 63104 Contact 314-577-8764 Principal Investigator: Bruce Bacon United States, Ohio UH Cleveland Medical Center Not yet recruiting Cleveland, Ohio, United States, 44106 Contact 216-844-5387 Principal Investigator: Anthony Post United States, Texas Baylor College of Medicine Not yet recruiting Houston, Texas, United States, 77030 Contact 713-798-1966 Principal Investigator: John Vierling Italy Azienda Ospedaliera San Gerardo Not yet recruiting Monza, Milano, Italy, 20052 Contact 390392333673 Principal Investigator: Pietro Invernizzi Istituto Clinico Humanitas Not yet recruiting Rozzano, Milano, Italy, 20089 Contact 390282244556 Principal Investigator: Ana Lleo De Nalda Azienda Ospedaliera Umberto I Not yet recruiting Ancona, Italy, 60124 Contact 390715963377 Principal Investigator: Marco Marzioni Puerto Rico Klinical Investigations Group, LLC Not yet recruiting San Juan, Puerto Rico, 00909 Contact 7879197865 Principal Investigator: Federico Rodriguez University of Puerto Rico, Medical Sciences Campus Not yet recruiting San Juan, Puerto Rico, 00936 Contact 7877540101 Principal Investigator: Esther A. Torres Collapse << |
NCT01896726 | Healthy Volunteers | Phase 1 | Completed | - | United Kingdom ... more >> For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician. Leeds, West Yorkshire, United Kingdom, LS2 9LH Collapse << |
NCT03334422 | Atopic Dermatitis | Phase 3 | Active, not recruiting | January 9, 2019 | - |
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NCT01937026 | - | - | Completed | - | - |
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NCT02759731 | Chronic Graft vs Host Disease ... more >> Chronic Graft-Versus-Host Disease Collapse << | Phase 1 Phase 2 | Recruiting | June 1, 2020 | United States, Maryland ... more >> National Institutes of Health Clinical Center Recruiting Bethesda, Maryland, United States, 20892 Contact: For more information at the NIH Clinical Center contact National Cancer Institute Referral Office 888-624-1937 Collapse << |
NCT01925144 | - | - | Completed | - | - |
NCT01925144 | Healthy Volunteers | Phase 1 | Completed | - | United Kingdom ... more >> For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician. Leeds, West Yorkshire, United Kingdom, LS2 9LH Collapse << |
NCT01910311 | Healthy Volunteers | Phase 1 | Completed | - | United Kingdom ... more >> For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician. Leeds, West Yorkshire, United Kingdom, LS2 9LH Collapse << |
NCT03773978 | Juvenile Idiopathic Arthritis | Phase 3 | Not yet recruiting | September 18, 2021 | Brazil ... more >> LMK Serviços Médicos S/S Not yet recruiting Porto Alegre, Rio Grande Do Sul, Brazil, 90540-000 Contact 555130613440 Principal Investigator: Maria Mercedes Caracciolo Picarelli Hospital de Clinicas de Porto Alegre Not yet recruiting Porto Alegre, RS, Brazil, 90035-903 Contact 555133597662 Principal Investigator: Claiton Viegas Brenol Faculdade de Medicina de Botucatu Not yet recruiting Botucatu, Sao Paulo, Brazil, 18618-970 Contact 551438801663 Principal Investigator: Claudia Saad Magalhães Faculdade de Ciências Médicas - UNICAMP Not yet recruiting Campinas, Sao Paulo, Brazil, 13083-887 Contact 551935219421 Principal Investigator: Simone Appenzeller Universidade Federal de São Paulo - Escola Paulista de Medicina Not yet recruiting São Paulo, Brazil, 04038-001 Contact 551155747627 Principal Investigator: Maria Teresa Terreri Germany Universitätsklinikum Heidelberg Not yet recruiting Heidelberg, Baden-Württemberg, Germany, 69120 Contact 496221564823 Principal Investigator: Thomas Lutz Universitätsklinikum Tübingen Not yet recruiting Tübingen, Baden-Württemberg, Germany, 72076 Contact 4970712980901 Principal Investigator: Jasmin Kümmerle-Deschner Asklepios Klinik Sankt Augustin GmbH Not yet recruiting Saint Augustin, Nordrhein-Westfalen, Germany, 53757 Contact 492149249201 Principal Investigator: Gerd Horneff HELIOS Klinikum Berlin-Buch Not yet recruiting Berlin, Germany, 13125 Contact 4930940114510 Principal Investigator: Ralf Trauzeddel Charité Universitätsmedizin Berlin Not yet recruiting Berlin, Germany, 13353 Contact 4930450566528 Principal Investigator: Kirsten Minden Hamburger Zentrum für Kinder und Jugendrheumatologie Not yet recruiting Hamburg, Germany, 22081 Contact 494020923694 Principal Investigator: Ivan Foeldvari Japan Kanazawa University Hospital Recruiting Kanazawa, Ishikawa, Japan, 920 8641 Contact 81120360605 Principal Investigator: Masaki Shimizu Kanagawa Prefectural Childrens Medical Center Not yet recruiting Yokohama, Kanagawa, Japan, 232-0066 Contact 81120360605 Principal Investigator: Tomoyuki Imagawa Yokohama City University Hospital Not yet recruiting Yokohama, Kanagawa, Japan, 236-0004 Contact 81120360605 Principal Investigator: Shuichi Ito Miyagi Children's Hospital Recruiting Sendai-shi, Miyagi, Japan, 989 3126 Contact 81120360605 Principal Investigator: Yoshihiro Umebayashi Osaka Medical College Hospital Not yet recruiting Takatsuki, Osaka, Japan, 569-8686 Contact 81120360605 Principal Investigator: Kosuke Syabana Saitama Children's Medical Center Not yet recruiting Saitama-shi, Saitama, Japan, 330 8777 Contact 81120360605 Principal Investigator: Yutaka Kawano Tokyo Medical And Dental University Hospital Not yet recruiting Bunkyo-ku, Tokyo, Japan, 113-8519 Contact 81120360605 Principal Investigator: Masaaki Mori St. Lukes International Hospital Not yet recruiting Chuo-Ku, Tokyo, Japan, 104 8560 Contact 81120360605 Principal Investigator: Kenichi Yamaguchi Kagoshima University Hospital Not yet recruiting Kagoshima, Japan, 890-8520 Contact 81120360605 Principal Investigator: Yoshifumi Kawano Niigata University Medical & Dental Hospital Not yet recruiting Niigata, Japan, 951-8520 Contact 81120360605 Principal Investigator: Utako Kaneko Mexico CREA de Guadalajara, S.C. Not yet recruiting Guadalajara, Jalisco, Mexico, 44620 Contact 5233336483333 Principal Investigator: Gabriel Vega Cornejo Hospital Univ. "Dr. José Eleuterio González" Not yet recruiting Monterrey, Nuevo León, Mexico, 64460 Contact 83338623 Principal Investigator: Nadina Eugenia Rubio Perez Cemdeicy S.C.P. Not yet recruiting Merida, Yucatán, Mexico, 97130 Contact 529992863277 Principal Investigator: Efren Alberto Canul Novelo Investigación y Biomedicina de Chihuahua, SC Not yet recruiting Chihuahua, Mexico, 31000 Contact 526144373003 Principal Investigator: Cesar Pacheco Tena Instituto de Investigaciones Aplicadas a la Neurociencia A.C Not yet recruiting Durango, Mexico, 34000 Contact 526181963882 Principal Investigator: Edgar Hernandez Vargas Russian Federation V.A. Nasonova Research Institute of Rheumatology Not yet recruiting Moscow, Russian Federation, 115522 Contact 74996143965 Principal Investigator: Irina Nikishina Morozov Children's City Hospital Not yet recruiting Moscow, Russian Federation, 119049 Contact 74959598800 Principal Investigator: Saniya Valieva Center of Children`s Health Not yet recruiting Moscow, Russian Federation, 119991 Contact 84959671420 Principal Investigator: Ekaterina Alexeeva First Moscow State Medical University n.a. Sechenov Not yet recruiting Moscow, Russian Federation, 119991 Contact 84992480181 Principal Investigator: Elena Zholobova St. Petersburg State Pediatric Medical University Not yet recruiting Saint-Petersburg, Russian Federation, 194100 Contact 78122950646 Principal Investigator: Vyacheslav Chasnyk Collapse << |
NCT02758613 | - | - | Completed | - | - |
NCT01968057 | - | - | Completed | - | - |
NCT02263911 | - | - | Completed | - | - |
NCT01870388 | Liver Diseases ... more >> Hepatic Insufficiency Collapse << | Phase 1 | Completed | - | United States, Florida ... more >> For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician. Miami, Florida, United States, 33014 For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician. Orlando, Florida, United States, 32806 Collapse << |
NCT01968057 | Healthy Volunteers | Phase 1 | Completed | - | United Kingdom ... more >> For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician. Leeds, West Yorkshire, United Kingdom, LS2 9LH Collapse << |
NCT01870388 | - | - | Completed | - | - |
NCT03026504 | Arteritis, Giant Cell | Phase 2 | Recruiting | June 2021 | United States, Minnesota ... more >> Mayo Clinic Recruiting Rochester, Minnesota, United States, 55905 Collapse << |
NCT02758613 | Healthy | Phase 1 | Completed | - | China ... more >> For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri, 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST) or speak with your personal physician. Beijing, China, 100034 Collapse << |
NCT03212638 | Healthy | Phase 1 | Completed | - | Singapore ... more >> For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri, 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST) or speak with your personal physician. Singapore, Singapore Collapse << |
NCT02340104 | Healthy Volunteers | Phase 1 | Completed | - | United Kingdom ... more >> For additional information regarding investigative sites for this trial, contact 1‐877‐CTLILLY Leeds, Yorkshire, United Kingdom, LS2 9LH Collapse << |
NCT03701789 | Rheumatoid Arthritis ... more >> Bone Density Finger Joints Collapse << | Phase 3 | Active, not recruiting | September 11, 2020 | Germany ... more >> Universitiy Hospital Erlangen Erlangen, Bavaria, Germany, 91052 Collapse << |
NCT03773965 | Juvenile Idiopathic Arthritis | Phase 3 | Not yet recruiting | August 19, 2027 | Argentina ... more >> Instituto Centralizado de Asistencia e Investigacion Clinica Not yet recruiting Rosario, Santa Fe, Argentina, 2000 Contact 543415290086 Principal Investigator: Diego Viola Brazil LMK Serviços Médicos S/S Not yet recruiting Porto Alegre, Rio Grande Do Sul, Brazil, 90540-000 Contact 555130613440 Principal Investigator: Maria Mercedes Caracciolo Picarelli Hospital de Clinicas de Porto Alegre Not yet recruiting Porto Alegre, RS, Brazil, 90035-903 Contact 555133597662 Principal Investigator: Joao C. Brenol Faculdade de Medicina de Botucatu Not yet recruiting Botucatu, Sao Paulo, Brazil, 18618-970 Contact 551438801663 Principal Investigator: Claudia Saad Magalhães Hospital de Clinicas UNICAMP Not yet recruiting Campinas, São Paulo, Brazil, 13083-887 Contact 551935219421 Principal Investigator: Simone Appenzeller Universidad Federal São Paulo Not yet recruiting São Paulo, Brazil, 04038-001 Contact 551155747627 Principal Investigator: Maria Teresa Terreri Japan Kanazawa University Hospital Recruiting Kanazawa, Ishikawa, Japan, 920 8641 Contact 81120360605 Principal Investigator: Masaki Shimizu Kanagawa Prefectural Childrens Medical Center Not yet recruiting Yokohama, Kanagawa, Japan, 232-0066 Contact 81120360605 Principal Investigator: Tomoyuki Imagawa Yokohama City University Hospital Not yet recruiting Yokohama, Kanagawa, Japan, 236-0004 Contact 81120360605 Principal Investigator: Shuichi Ito Miyagi Children's Hospital Recruiting Sendai-shi, Miyagi, Japan, 989 3126 Contact 81120360605 Principal Investigator: Yoshihiro Umebayashi Osaka Medical College Hospital Not yet recruiting Takatsuki, Osaka, Japan, 569-8686 Contact 81120360605 Principal Investigator: Kosuke Syabana Saitama Children's Medical Center Not yet recruiting Saitama-shi, Saitama, Japan, 330 8777 Contact 81120360605 Principal Investigator: Yutaka Kawano Tokyo Medical And Dental University Hospital Not yet recruiting Bunkyo-ku, Tokyo, Japan, 113-8519 Contact 81120360605 Principal Investigator: Masaaki Mori St. Lukes International Hospital Not yet recruiting Chuo-Ku, Tokyo, Japan, 104 8560 Contact 81120360605 Principal Investigator: Kenichi Yamaguchi Kagoshima University Hospital Not yet recruiting Kagoshima, Japan, 890-8520 Contact 81120360605 Principal Investigator: Yoshifumi Kawano Niigata University Medical & Dental Hospital Not yet recruiting Niigata, Japan, 951-8520 Contact 81120360605 Principal Investigator: Utako Kaneko Mexico CREA de Guadalajara, S.C. Not yet recruiting Guadalajara, Jalisco, Mexico, 44620 Contact 5233336483333 Principal Investigator: Gabriel Vega Cornejo Hospital Univ. "Dr. José Eleuterio González" Not yet recruiting Monterrey, Nuevo León, Mexico, 64460 Principal Investigator: Nadina Eugenia Rubio Perez Cemdeicy S.C.P. Not yet recruiting Merida, Yucatán, Mexico, 97130 Contact 529992863277 Principal Investigator: Efren Alberto Canul Novelo Investigación y Biomedicina de Chihuahua, SC Not yet recruiting Chihuahua, Mexico, 31000 Contact 526144155012 Principal Investigator: Cesar Pacheco Tena Instituto de Investigaciones Aplicadas a la Neurociencia A.C Not yet recruiting Durango, Mexico, 34000 Contact 526181963882 Principal Investigator: Edgar Hernandez Vargas Collapse << |
NCT03559270 | Atopic Dermatitis | Phase 3 | Enrolling by invitation | July 19, 2021 | - |
NCT02340104 | - | - | Completed | - | - |
靶点 | Description | IC50 |
---|---|---|
JAK1 | IC50:5.9nM | |
JAK2 | IC50:5.7nM |
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